The first renovation of the Cathedral took place in 1901 after lightning struck the steeple, destroying the parish church in a fire. For two years, renovations on the church were made. The length of the church was extended to the west, transepts were added, and the vaulted ceiling, supported by columns, was erected to cover the charrred beams. Additional pews were added to accommodate 1,300 people. A second renovation was begun in 1961, a third in 1979, and the most recent in 1998.

During the most recent renovation, the baptismal font was relocated to the entrance of the church; new bas-relief Stations of the Cross were added; the vaulted ceiling was painted in shades of blue with gold-leaf trim and a symbolic arrangement of stars; a painting of Our Lady of Guadalupe, Patroness of the Americas, now overlooks the assembly. Statues for the restored reredos and new organs have also been added. New wiring, sound system, ventilation system and flooring were installed. Improvements to the basement include additional meeting rooms and restrooms, a a renovated parish center, and a larger kitchen